A new zero-day vulnerability (CVE-2017-7269) impacting Microsoft IIS 6.0 has been announced with proof-of-concept code. This vulnerability can only be exploited if WebDAV is enabled. IIS 6.0 is a component of Microsoft Windows Server 2003 (including R2.) Microsoft has ended support for Server 2003 on July 14, 2015, which means that this vulnerability will most likely not be patched. It is recommended that these systems be upgraded to a supported platform. The current workaround is to disable the WebDAV Web Service Extension if it is not needed by any web applications.
The Qualys Cloud Platform can help you detect the vulnerability, track and manage Server 2003 Assets, as well as block exploits against web-based vulnerabilities like this one.